Background: Anxiety reactions and panic attacks are the acute symptoms most frequently associated with cannabis use. Understanding the relationship between cannabis and anxiety may clarify the mechanism of action of cannabis and the pathophysiology of anxiety. Aims of the present study were to review the nature of the relationship between cannabis use and anxiety, as well as the possible clinical, diagnostic and causal implications.
Method: Systematic review of the Medline, PsycLIT and EMBASE literature.
Results: Frequent cannabis users consistently have a high prevalence of anxiety disorders and patients with anxiety disorders have relatively high rates of cannabis use. However, it is unclear if cannabis use increases the risk of developing long-lasting anxiety disorders. Many hypotheses have been proposed in an attempt to explain these relationships, including neurobiological, environmental and social influences.
Conclusions: The precise relationship between cannabis use and anxiety has yet to be established. Research is needed to fully clarify the mechanisms of such the association.
Shalit N, Lev-Ran S. Shalit N, et al. Curr Opin Psychiatry. 2020 Jan;33(1):8-13. doi: 10.1097/YCO.0000000000000560. Curr Opin Psychiatry. 2020. PMID: 31592815 Review.
Thomas H. Thomas H. Br J Psychiatry. 1993 Aug;163:141-9. doi: 10.1192/bjp.163.2.141. Br J Psychiatry. 1993. PMID: 8075903 Review.
Casadio P, Fernandes C, Murray RM, Di Forti M. Casadio P, et al. Neurosci Biobehav Rev. 2011 Aug;35(8):1779-87. doi: 10.1016/j.neubiorev.2011.04.007. Epub 2011 Apr 16. Neurosci Biobehav Rev. 2011. PMID: 21530584
Coscas S, Benyamina A, Reynaud M, Karila L. Coscas S, et al. Rev Prat. 2013 Dec;63(10):1426-8. Rev Prat. 2013. PMID: 24579344 Review. French.
Zvolensky MJ, Bernstein A, Sachs-Ericsson N, Schmidt NB, Buckner JD, Bonn-Miller MO. Zvolensky MJ, et al. J Psychiatr Res. 2006 Sep;40(6):477-86. doi: 10.1016/j.jpsychires.2005.09.005. Epub 2005 Nov 3. J Psychiatr Res. 2006. PMID: 16271364
Giossi R, Mercenari M, Filippi M, Zanetta C, Antozzi CG, Brambilla L, Confalonieri P, Crisafulli SG, Tomas Roldan E, Annovazzi P, Conti MZ, Barrilà C, Ronzoni M, Grobberio M, Negri A, Gustavsen S, Torri Clerici V. Giossi R, et al. J Neurol. 2024 Jun 7. doi: 10.1007/s00415-024-12472-4. Online ahead of print. J Neurol. 2024. PMID: 38844694
N Pavel A, Paun R, P Matei V. N Pavel A, et al. Psychiatry Clin Psychopharmacol. 2021 Jun 1;31(2):226-232. doi: 10.5152/pcp.2021.21743. eCollection 2021 Jun. Psychiatry Clin Psychopharmacol. 2021. PMID: 38765233 Free PMC article. Review.
Córdoba-Grueso WS, Galaviz KI, Parker MA. Córdoba-Grueso WS, et al. PLoS One. 2024 Apr 11;19(4):e0301253. doi: 10.1371/journal.pone.0301253. eCollection 2024. PLoS One. 2024. PMID: 38603706 Free PMC article.
Myran DT, Harrison LD, Pugliese M, Tanuseputro P, Gaudreault A, Fiedorowicz JG, Solmi M. Myran DT, et al. EClinicalMedicine. 2024 Feb 5;69:102455. doi: 10.1016/j.eclinm.2024.102455. eCollection 2024 Mar. EClinicalMedicine. 2024. PMID: 38544799 Free PMC article.
Loreto BBL, Sordi AO, de Castro MN, Ornell F, Guarnieri EP, Roza TH, Schuch JB, Cima MDS, Pechansky F, Grevet EH, Grassi-Oliveira R, von Diemen L, Kessler FHP. Loreto BBL, et al. Front Psychiatry. 2024 Jan 11;14:1298002. doi: 10.3389/fpsyt.2023.1298002. eCollection 2023. Front Psychiatry. 2024. PMID: 38274436 Free PMC article.